Vanadium Oxide Cathode Coinserted by Ni2+ and NH4+ for High-Performance Aqueous Zinc-Ion Batteries.

Vanadium-based oxides have garnered significant attention as cathode materials for aqueous zinc-ion batteries (AZIBs) because of their high theoretical capacity and low cost. However, the limited reaction kinetics and poor long-term cycle stability hinder their widespread application. In this paper, we propose a novel approach by coinserting Ni2+ and NH4+ ions into V2O5·3H2O, i.e., NNVO. Structural characterization shows that the coinsertion of Ni2+ and NH4+ not only extends the interlayer spacing of V2O5·3H2O but also significantly promotes the transport kinetics of Zn2+ because of the synergistic "pillar" effect of Ni2+ and NH4+, as well as the increased oxygen vacancies that effectively lower the energy barrier for Zn2+ insertion. As a result, the AZIBs with an NNVO electrode exhibit a high capacity of 398.1 mAh g-1 (at 1.0 A g-1) and good cycle stability with 89.1% capacity retention even after 2000 cycles at 5.0 A g-1. At the same time, a highly competitive energy density of 262.9 Wh kg-1 is delivered at 382.9 W kg-1. Considering the simple scheme and the resultant high performance, this study may provide a positive attempt to develop high-performance AZIBs.

The relationship between alterations in plasma metabolites and treatment responses in antipsychotic-naïve female patients with schizophrenia.

This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment. Receiver operator characteristics (ROC) curves were used to predict diagnostic and therapeutic responses. A total of 186 metabolites passed quality control procedures and were used in statistical analysis to identify potential biomarkers. Before treatment, the ANS patients had lower levels of γ -Aminobutyric Acid (GABA) and higher levels of Cholesteryl esters (CE) (20:3), Cholic Acid (CA) and Glycocholic Acid (GCA) compared to the HCs. These four differential metabonomic markers were synthesised into a combinatorial biomarker panel. This panel significantly distinguished ANS from HC. Moreover, this biomarker panel was able to effectively predict therapeutic responses. Our results suggest that plasma CE (20:3), CA, GCA, and GABA levels may be useful for diagnosing and predicting antipsychotic efficacy amongst female schizophrenia patients.

Interlayer and Phase Engineering Modifications of K-MoS2@C Nanoflowers for High-Performance Degradable Zn-Ion Batteries.

2D transition metal dichalcogenides (TMDs) have garnered significant interest as cathode materials for aqueous zinc-ion batteries (AZIBs) due to their open transport channels and abundant Zn2+ intercalation sites. However, unmodified TMDs exhibit low electrochemical activity and poor kinetics owing to the high binding energy and large hydration radius of divalent Zn2+. To overcome these limitations, an interlayer engineering strategy is proposed where K+ is preintercalated into K-MoS2 nanosheets, which then undergo in situ growth on carbon nanospheres (denoted as K-MoS2@C nanoflowers). This strategy stimulates in-plane redox-active sites, expands the interlayer spacing (from 6.16 to 9.42 Å), and induces the formation of abundant MoS2 1T-phase. The K-MoS2@C cathode demonstrates excellent redox activity and fast kinetics, attributed to the potassium ions acting as a structural "stabilizer" and an electrostatic interaction "shield," accelerating charge transfer, promoting Zn2+ diffusion, and ensuring structural stability. Meanwhile, the carbon nanospheres serve as a 3D conductive network for Zn2+ and enhance the cathode's hydrophilicity. More significantly, the outstanding electrochemical performance of K-MoS2@C, along with its superior biocompatibility and degradability of its related components, can enable an implantable energy supply, providing novel opportunities for the application of transient electronics.

Multifunctional injectable hydrogels with controlled delivery of bioactive factors for efficient repair of intervertebral disc degeneration.

Millions of people worldwide suffer from intervertebral disc degeneration (IVDD), which imposes a significant socioeconomic burden on society. There is an urgent clinical demand for more effective treatments for IVDD because conventional treatments can only alleviate the symptoms rather than preventing the progression of IVDD. Hydrogels, a class of elastic biomaterials with good biocompatibility, are promising candidates for intervertebral disc repair and regeneration. In recent years, various hydrogels have been investigated in vitro and in vivo for the repair of intervertebral discs, some of which are ready for clinical testing. This review summarizes the latest findings and developments in using bioactive factors-released bioactive injectable hydrogels for the repair and regeneration of intervertebral discs. It focuses on the analysis and summary of the use of multifunctional injectable hydrogels to delivery bioactive factors (cells, exosomes, growth factors, genes, drugs) for disc regeneration, providing guidance for future study. Finally, we discussed and analyzed the optimal timing for the application of controlled-release hydrogels in the treatment of IVDD to meet the high standards required for intervertebral disc regeneration and precision medicine.

A soft implantable energy supply system that integrates wireless charging and biodegradable Zn-ion hybrid supercapacitors.

The advent of implantable bioelectronic devices offers prospective solutions toward health monitoring and disease diagnosis and treatments. However, advances in power modules have lagged far behind the tissue-integrated sensor nodes and circuit units. Here, we report a soft implantable power system that monolithically integrates wireless energy transmission and storage modules. The energy storage unit comprises biodegradable Zn-ion hybrid supercapacitors that use molybdenum sulfide (MoS2) nanosheets as cathode, ion-crosslinked alginate gel as electrolyte, and zinc foil as anode, achieving high capacitance (93.5 mF cm-2) and output voltage (1.3 V). Systematic investigations have been conducted to elucidate the charge storage mechanism of the supercapacitor and to assess the biodegradability and biocompatibility of the materials. Furthermore, the wirelessly transmitted energy can not only supply power directly to applications but also charge supercapacitors to ensure a constant, reliable power output. Its power supply capabilities have also been successfully demonstrated for controlled drug delivery.

LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918.

BACKGROUND: Reportedly, ovarian cancer (OC) is a major threat to women's health. Long non-coding RNA (lncRNA) ASB16-AS1 has been uncovered to participate in cancer progression. Nevertheless, the role of ASB16-AS1 in OC remains to be revealed. PURPOSE: This study aimed to unveil the biological function of ASB16-AS1 and its underlying mechanisms in OC cells. METHODS: QRT-PCR was done to test ASB16-AS1 expression in OC cells. Functional assays were performed to evaluate the malignant behaviors and cisplatin resistance of OC cells. Mechanistic analyses were done to investigate the regulatory molecular mechanism in OC cells. RESULTS: ASB16-AS1 was found to be highly expressed in OC cells. ASB16-AS1 knockdown repressed proliferation, migration, and invasion of OC cells, while facilitating cell apoptosis. ASB16-AS1 was further validated to up-regulate GOLM1 through competitively binding with miR-3918. Moreover, miR-3918 overexpression was corroborated to suppress OC cell growth. Rescue assays further uncovered that ASB16-AS1 modulated the malignant processes of OC cells via targeting miR-3918/GOLM1 axis. CONCLUSION: ASB16-AS1 facilitates the malignant processes and chemoresistance of OC cells via serving as miR-3918 sponge and positively modulating GOLM1 expression.

A Biocompatible Supercapacitor Diode with Enhanced Rectification Capability toward Ion/Electron-Coupling Logic Operations.

The main challenge faced by the forthcoming human-computer interaction is that biological systems and electronic devices adopt two different information carriers, i.e., ions and electrons, respectively. To bridge the gap between these two systems, developing ion/electron-coupling devices for logic operation is a feasible and effective approach. Accordingly, herein a supercapacitor-based ionic diode (CAPode) that takes electrochemically amorphized molybdenum oxide as the working electrode is developed. Benefiting from its unique size and charge dual ion-sieving effects, the molybdenum oxide electrode exhibits a record-high rectification ratio of 136, which is over 10 times higher than those of reported systems. It also delivers an ultrahigh specific capacitance of 448 F g⁻1 and an excellent cycling stability of up to 20 000 cycles, greatly outperforming those of previous works. These excellent rectification capability and electrochemical performances allow the as-built CAPode to work well in AND and OR logic gates, validating great potential in ion/electron-coupling logic operations. More attractively, the superior biocompatibilities of molybdenum oxide and relevant constituent materials enable the constructed CAPode to be applied as bioelectronics without regard to biosafety, paving a new way toward forthcoming human-computer interaction.

Engineering Multifunctional Polyether Ether Ketone Implant: Mechanics-Adaptability, Biominerialization, Immunoregulation, Anti-Infection, Osteointegration, and Osteogenesis.

Polyether ether ketone (PEEK) has become one of the most promising polymer implants in bone orthopedics, due to the biocompatibility, good processability, and radiation resistance. However, the poor mechanics-adaptability/osteointegration/osteogenesis/antiinfection limits the long-term in vivo applications of PEEK implants. Herein, a multifunctional PEEK implant (PEEK-PDA-BGNs) is constructed through in situ surface deposition of polydopamine-bioactive glass nanoparticles (PDA-BGNs). PEEK-PDA-BGNs exhibit good performance on osteointegration and osteogenesis in vitro and in vivo, due to their multifunctional properties including mechanics-adaptability, biominerialization, immunoregulation, anti-infection, and osteoinductive activity. PEEK-PDA-BGNs can show the bone tissue-adaptable mechanic surface and induce the rapid biomineralization (apatite formation) under a simulated body solution. Additionally, PEEK-PDA-BGNs can induce the M2 phenotype polarization of macrophages, reduce the expression of inflammatory factors, promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and improve the osseointegration and osteogenesis ability of the PEEK implant. PEEK-PDA-BGNs also show good photothermal antibacterial activity and can kill 99% of Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA), suggesting their potential antiinfection ability. This work suggests that PDA-BGNs coating is probably a facile strategy to construct multifunctional (biomineralization, antibacterial, immunoregulation) implants for bone tissue replacement.

High-Performance Biodegradable Energy Storage Devices Enabled by Heterostructured MoO3 -MoS2 Composites.

Biodegradable implantable devices are of growing interest in biosensors and bioelectronics. One of the key unresolved challenges is the availability of power supply. To enable biodegradable energy-storage devices, herein, 2D heterostructured MoO3 -MoS2 nanosheet arrays are synthesized on water-soluble Mo foil, showing a high areal capacitance of 164.38 mF cm-2 (at 0.5 mA cm-2 ). Employing the MoO3 -MoS2 composite as electrodes of a symmetric supercapacitor, an asymmetric Zn-ion hybrid supercapacitor, and an Mg primary battery are demonstrated. Benefiting from the advantages of MoO3 -MoS2 heterostructure, the Zn-ion hybrid supercapacitors deliver a high areal capacitance (181.86 mF cm-2 at 0.5 mA cm-2 ) and energy density (30.56 µWh cm-2 ), and the Mg primary batteries provide a stable high output voltage (≈1.6 V) and a long working life in air/liquid environment. All of the used materials exhibit desirable biocompatibility, and these fabricated devices are also fully biodegradable. Demonstration experiments display their potential applications as biodegradable power sources for various electronic devices.

Inhibiting the Dissolution of Lithium Polyphosphides and Enhancing the Reaction Kinetics of a Phosphorus Anode via Screening Functional Additives.

A high-capacity, low-cost phosphorus anode is considered as one of the most promising candidates for next-generation Li-ion batteries. Nevertheless, the dissolution/shuttle effect of lithium polyphosphides and sluggish electrochemical conversion hinder the practical application of a phosphorus anode, similar to the problems of a sulfur cathode. Although the reported functional additives with physical obstruction and chemical adsorption have been successful in improving the performance of a sulfur cathode, they can not be directly applied to phosphorus due to their deterioration and failure in low voltage. To solve the above problems, we made a systematic investigation to rationally select the functional additives (Li2O, Li2S, and LiF) and effectively guide the experiment. These functional additives possess synergetic effects, including the adsorption of soluble lithium polyphosphides and the catalytic conversion of phosphorus species. The design of these functional additives provides a guiding and screening principle for inhibiting the dissolution of polyphosphides and improving the reaction kinetics of a phosphorus anode.

Total hip arthroplasty for posttraumatic osteoarthritis secondary to acetabular fracture: An evidence based on 1,284 patients from 1970 to 2018.

Background: Posttraumatic osteoarthritis (PTOA) can be a crippling sequela of acetabular fracture (AF), and total hip arthroplasty (THA) is often necessary to alleviate the clinical progression of symptoms. The purpose of this study was to summarize the existing clinical evidence concerning the surgical management of AF with THA through meta-analyses. Methods: Databases were searched for articles published between 1995 and January 2022 that contained the keywords "acetabular," "fracture," "arthroplasty," and "osteoarthritis." Our study was registered in PROSPERO under number CRD42022314997. Results: We screened 3,125 studies and included data from 31 studies with 1,284 patients. The median patient age at the time of THA was 52 years and ranged from 19 to 94 years. The pooled overall survival rate was 88% [86%-90%, 95% confidence interval (CI)] and could reach 83% at ≥15-year follow-up. For the Harris Hip Score, we pooled 22 studies with an overall mean difference of 43.25 (40.40-46.10, 95% CI; P < 0.001), indicating a large clinical effect. The pooled complications (incidence rates) across studies were: heterotopic ossification (22.53%), implant dislocation (4.66%), implant infection (3.44%), and iatrogenic nerve injury (1.07%). Conclusion: THA in patients with PTOA following AF leads to significant improvement in symptoms and function at ≥15-year follow-up. Survival rates of implants free from re-operation or revision after THA decreased with follow-up time and could still reach 83% at ≥15-year follow-up. THA might be an effective therapeutic method for patients with PTOA due to AF.

Superelastic graphene aerogel-based metamaterials.

Ultralight, ultrastrong, and supertough graphene aerogel metamaterials combining with multi-functionalities are promising for future military and domestic applications. However, the unsatisfactory mechanical performances and lack of the multiscale structural regulation still impede the development of graphene aerogels. Herein, we demonstrate a laser-engraving strategy toward graphene meta-aerogels (GmAs) with unusual characters. As the prerequisite, the nanofiber-reinforced networks convert the graphene walls' deformation from the microscopic buckling to the bulk deformation during the compression process, ensuring the highly elastic, robust, and stiff nature. Accordingly, laser-engraving enables arbitrary regulation on the macro-configurations of GmAs with rich geometries and appealing characteristics such as large stretchability of 5400% reversible elongation, ultralight specific weight as small as 0.1 mg cm-3, and ultrawide Poisson's ratio range from -0.95 to 1.64. Additionally, incorporating specific components into the pre-designed meta-structures could further achieve diversified functionalities.

lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN.

Objective: Long noncoding RNA neuroblastoma-associated transcript 1 (NBAT1) is implicated in the progression of various cancers. Nevertheless, its biological function in endometrial cancer (EC) remains unknown. Methods: The levels of NBAT1, miR-21-5p, and PTEN in EC cells and EC tissues were examined by RT-qPCR. Western blot was carried out to assess the protein expression of PTEN. The dual-luciferase reporter assay was conducted to explore the interactions among NBAT1, miR-21-5p, and PTEN. The effect of NBAT1 on EC proliferation, metastasis, and apoptosis was evaluated by CCK-8, transwell assays, wound healing, and flow cytometry. miR-21-5p mimics or NBAT1+miR-21-5p were transfected into HEC-1A and Ishikawa cells to investigate whether NBAT1 regulated EC tumorigenesis via sponging miR-21-5p. Results: NBAT1 is downregulated, and miR-21-5p is upregulated in EC cells and tumor tissues. Overexpression of NBAT1 inhibits the proliferation, migration, and invasion abilities of EC cells and facilitated apoptosis. NBAT1 directly binds and negatively regulates miR-21-5p in EC. miR-21-5p mimics reverses the effect of lncRNA NBAT1 overexpression on the proliferation and migration of EC cells. PTEN is a downstream gene of miR-21-5p. lncRNA NBTA1 elevates PTEN expression via sponging miR-21-5p. Conclusions: lncRNA NBAT1 acts as a tumor suppressor in EC via regulating PTEN through sponging miR-21-5p.

A reconfigurable and magnetically responsive assembly for dynamic solar steam generation.

Interfacial solar vapor generation is a promising technique to efficiently get fresh water from seawater or effluent. However, for the traditional static evaporation models, further performance improvement has encountered bottlenecks due to the lack of dynamic management and self-regulation on the evolving water movement and phase change in the evaporation process. Here, a reconfigurable and magnetically responsive evaporator with conic arrays is developed through the controllable and reversible assembly of graphene wrapped Fe3O4 nanoparticles. Different from the traditional structure-rigid evaporation architecture, the deformable and dynamic assemblies could reconfigure themselves both at macroscopic and microscopic scales in response to the variable magnetic field. Thus, the internal water transportation and external vapor diffusion are greatly promoted simultaneously, leading to a 23% higher evaporation rate than that of static counterparts. Further, well-designed hierarchical assembly and dynamic evaporation system can boost the evaporation rate to a record high level of 5.9 kg m-2 h-1. This proof-of-concept work demonstrates a new direction for development of high performance water evaporation system with the ability of dynamic reconfiguration and reassembly.

Precision medicine strategies for spinal degenerative diseases: Injectable biomaterials with in situ repair and regeneration.

As the population ages, spinal degeneration seriously affects quality of life in middle-aged and elderly patients, and prevention and treatment remain challenging for clinical surgeons. In recent years, biomaterials-based injectable therapeutics have attracted much attention for spinal degeneration treatment due to their minimally invasive features and ability to perform precise repair of irregular defects. However, the precise design and functional control of bioactive injectable biomaterials for efficient spinal degeneration treatment remains a challenge. Although many injectable biomaterials have been reported for the treatment of spinal degeneration, there are few reviews on the advances and effects of injectable biomaterials for spinal degeneration treatment. This work reviews the current status of the design and fabrication of injectable biomaterials, including hydrogels, bone cements and scaffolds, microspheres and nanomaterials, and the current progress in applications for treating spinal degeneration. Additionally, registered clinical trials were also summarized and key challenges and clinical translational prospects for injectable materials for the treatment of spinal degenerative diseases are discussed.

Fuzzy comprehensive evaluation with AHP and entropy methods and health risk assessment of groundwater in Yinchuan Basin, northwest China.

Water quality evaluation and health risk assessment are not only the basis of environmental protection work, but also of great significance to water environment supervision and management. In this paper, the fuzzy comprehensive evaluation for water quality was improved by using the analytic hierarchy process (AHP) and Entropy, and a health risk assessment model based on triangular fuzzy theory was developed. The evaluation results show 5 water categories: Class-1 (n = 1, 2%), Class-2 (n = 14, 32%), Class-3 (n = 15, 34%), Class-4 (n = 8, 18%) and Class-5 (n = 6, 14%), manifesting about 67% of the phreatic water can be used for drinking purposes in the research area. The Chadha diagram provides hydrochemical facies of the phreatic water are mainly NaCl type (n = 16, 36%) and Ca-Mg-Na type (n = 15, 34%). Fluorine as non-carcinogenic factor in health risk assessment, showing moderate correlation with SO42- (r = 0.54) and low correlation with Na+ (r = 0.38) in Pearson correlation analysis. The order of non-carcinogenic risk per year is as follow: Class-2, Class-3, All, Class-4 and Class-5 with the mean of 0.29, 0.51, 0.67, 0.86 and 1.55 × 10-8 for adults, 0.54, 0.95, 1.27, 1.58 and 2.89 × 10-8 for children. Compare with adults, children undertake higher health risk, in research area. Particularly, the region accepting Class-5 water supplement encounter high non-carcinogenic risk, where risk level is 2.24 and 2.28 times to the average risk level for adults and children, respectively. This paper provides insights into solving uncertainties in groundwater management and environmental protection, as well as into fuzzy logic techniques addressing pollution.

Host-Guest Intercalation Chemistry in MXenes and Its Implications for Practical Applications.

The ever-increasing demand on developing layered materials for practical applications, such as electrochemical energy storage, responsive materials, nanofluidics, and environmental remediation, requires the profound understanding and artful exploitation of interlayer engineering or intercalation chemistry. The past decade has witnessed the massive exploration of a recently discovered 2D material-transition metal carbides, carbonitrides, and nitrides (referred to as MXenes), which began to take hold of a myriad of applications owing to the abundant possibilities on their compositions and intercalation states. However, application-targeted manipulation of the material performance of MXenes is constrained by the dearth of deep comprehension on fundamental intercalation chemistry/physics. To this end, the aim of this review is to provide a holistic discussion on the intercalation chemistry in MXenes and the physical properties of MXene intercalation compounds. On the basis of this, potential solutions for the challenges confronted in the synthesis, tuning of material properties, and practical applications are proposed, which are also expected to reinvigorate the exploration of layered materials that are similar to MXenes.

A Cascade Battery: Coupling Two Sequential Electrochemical Reactions in a Single Battery.

Currently, rechargeable electrochemical batteries generally operate on one reversible electrochemical reaction during discharging and charging cycles. Here, a cascade battery that couples two sequential electrochemical reactions in a single battery is proposed. Such a concept is demonstrated in an aqueous Zn-S hybrid battery, where solid sulfur serves as the cathode in the first discharge step and the generated Cu2 S catalyzes Cu2+ reduce to Cu/Cu2 O to provide the second discharge step. The cascade battery shows many merits compared to traditional batteries. First, it integrates two batteries internally, eliminating the use of additional inactive connecting materials required for external integration. Second, it can more fully utilize the inactive reaction chamber of the battery than traditional batteries. Third, cascade battery can bypass the challenges of thick solid electrode to access high areal capacity. An ultrahigh areal capacity of 48 mAh cm-2 is achieved even at a low solid cathode loading (9.6 mg cm-2 ). The cascade battery design breaks the stereotype of conventional battery configuration, providing a paradigm for constructing two-in-one batteries.

Construction of Supercapacitor-Based Ionic Diodes with Adjustable Bias Directions by Using Poly(ionic liquid) Electrolytes.

The newly emerging supercapacitor-diode (CAPode), integrating the characteristics of a diode into an electrical-double-layer capacitor, can be employed to extend conventional supercapacitors to new technological applications and may play a crucial role in grid stabilization, signal propagation, and logic operations. However, the reported CAPodes have only been able to realize charge storage in the positive-bias direction. Here, bias-direction-adjustable CAPodes realized by using a polycation-based ionic liquid (IL) or a polyanion-based IL as electrolyte in an asymmetric carbon-based supercapacitor architecture are proposed. The resulting CAPodes exhibit charge-storage function at only the positive- or negative-bias direction with a high rectification ratio (≈80% for rectification ratio II, RRII ) and an outstanding cycling life (4500 cycles), representing a crucial breakthrough for designing high-performance capacitive ionic diodes.

Chemical compositions evolution of groundwater and its pollution characterization due to agricultural activities in Yinchuan Plain, northwest China.

Yinchuan Plain is a typically intensive cultivated region in the northwest of China. The irrigation return infiltration from Yellow River is the main source of groundwater recharge. Deep soil layers, sandy vadose zones, and dense irrigation canals make the groundwater susceptible to the return flow which contains pollutants originating mainly from agriculture applications, particularly from the extensive use of nitrogen fertilizer and manure. The pollution levels of phreatic water and confined water in NWS areas (non-water source areas) and WS areas (water source areas) of Yinchuan Plain in 2004 and 2014 were evaluated by the single-factor evaluation method, fuzzy comprehensive evaluation method, and average benchmark coefficient method, respectively. Piper trilinear diagram and scatter plots of major ions were used to classify water types and chemical facies, and further analyze the causes of groundwater pollution and the variation tendency of agricultural pollution. The results show that in 2014, about 50% of the groundwater samples were heavily polluted in Yinchuan Plain, the pollution level of phreatic water and confined water in NWS areas was up to level 5. And the groundwater within the standard in 2004 was heavily polluted in 2014 in WS areas, three-nitrogen pollution was the most serious pollutant, and the organic pollution level was grade IV. From the scatter plots of ions, it can be seen that the increase in concentrations of major ions was affected by evaporation-condensation and cation exchange reaction, but the complex ion contents indicated that groundwater was affected by human activities. The intensive agricultural activities, such as over fertilization, artificial irrigation, have led to concentrations increase of some chemical composition in groundwater.